Tunable stereoselective alkene synthesis by treatment of activated imines with nonstabilized phosphonium ylides.
نویسندگان
چکیده
A broad range of readily accessible N-sulfonyl imines undergo olefination reaction with nonstabilized phosphonium ylides under mild conditions to afford an array of both Z- and E-isomers of 1,2-disubstituted alkenes, allylic alcohols, and allylic amines in good yields and with greater than 99 : 1 stereoselectivity.
منابع مشابه
Stereoselective syntheses of the antihistaminic drug olopatadine and its E-isomer.
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 7 شماره
صفحات -
تاریخ انتشار 2011